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Takashi Kasukabe Selected Research

cotylenin A

3/2018Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis.
8/2015Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells.
2/2015Cotylenin A and arsenic trioxide cooperatively suppress cell proliferation and cell invasion activity in human breast cancer cells.
2/2013Inhibition of rapamycin-induced Akt phosphorylation by cotylenin A correlates with their synergistic growth inhibition of cancer cells.
8/2008Cotylenin A, a new differentiation inducer, and rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2.
4/2006Cotylenin A-induced differentiation is independent of the transforming growth factor-beta signaling system in human myeloid leukemia HL-60 cells.
12/2005Antitumor effect of cotylenin A plus interferon-alpha: possible therapeutic agents against ovary carcinoma.
1/2005Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts.

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Takashi Kasukabe Research Topics

Disease

11Neoplasms (Cancer)
10/2020 - 02/2003
8Leukemia
01/2018 - 05/2002
8Myeloid Leukemia (Leukemia, Myelocytic)
08/2016 - 05/2002
6Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
08/2015 - 02/2004
5Breast Neoplasms (Breast Cancer)
01/2018 - 01/2005
4Acute Promyelocytic Leukemia
08/2015 - 05/2002
3Pancreatic Neoplasms (Pancreatic Cancer)
03/2018 - 08/2016
3Hematologic Neoplasms (Hematological Malignancy)
01/2012 - 02/2003
2Lung Neoplasms (Lung Cancer)
10/2020 - 05/2003
2Necrosis
03/2018 - 08/2016
2Carcinoma (Carcinomatosis)
02/2013 - 12/2005
1Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome)
05/2018
1Hyperthermia
05/2018
1Neoplasm Metastasis (Metastasis)
01/2018
1Ovarian Neoplasms (Ovarian Cancer)
12/2005
1Neuroblastoma
10/2005
1Chromosome Aberrations (Chromosome Abnormalities)
02/2004
1Lymphoma (Lymphomas)
02/2003

Drug/Important Bio-Agent (IBA)

8cotylenin AIBA
03/2018 - 01/2005
6Plant Growth Regulators (Plant Hormones)IBA
03/2018 - 04/2006
6Proteins (Proteins, Gene)FDA Link
01/2012 - 06/2002
4Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2018 - 05/2002
3Reactive Oxygen Species (Oxygen Radicals)IBA
10/2020 - 03/2018
3Messenger RNA (mRNA)IBA
03/2018 - 05/2002
3Sirolimus (Rapamycin)FDA Link
02/2013 - 01/2005
2IronIBA
10/2020 - 03/2018
2Chelating AgentsIBA
10/2020 - 03/2018
2Deferoxamine (Desferal)FDA LinkGeneric
10/2020 - 03/2018
2AntioxidantsIBA
03/2018 - 07/2010
2benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA
03/2018 - 08/2016
2Biological ProductsIBA
03/2018 - 10/2009
2phenethyl isothiocyanate (PEITC)IBA
03/2018 - 08/2016
2Pharmaceutical PreparationsIBA
08/2015 - 07/2010
2Cyclin G2IBA
08/2015 - 08/2008
2TOR Serine-Threonine KinasesIBA
02/2013 - 08/2008
2Interferon-alpha (Interferon Alfa)IBA
12/2005 - 05/2003
1Auranofin (Ridaura)FDA Link
10/2020
1Oleic Acid (Oleate)IBA
10/2020
1coenzyme Q10 (CoQ10)IBA
10/2020
1Thioredoxin-Disulfide ReductaseIBA
10/2020
1idebenoneIBA
10/2020
1Monounsaturated Fatty AcidsIBA
10/2020
1PhosphatidylserinesIBA
05/2018
1CytokinesIBA
05/2018
1Annexin A5IBA
05/2018
1Sulfasalazine (Azulfidine)FDA LinkGeneric
03/2018
1piperlongumineIBA
03/2018
1Lysophosphatidic Acid ReceptorsIBA
01/2018
1lysophosphatidic acidIBA
01/2018
1quinoline-val-asp(OMe)-CH2-OPHIBA
08/2016
1Vitamin K 2 (Vitamin K2)IBA
08/2015
1Arsenic Trioxide (Trisenox)FDA Link
02/2015
1Ellagic AcidIBA
07/2010
1Transforming Growth Factor beta (TGF-beta)IBA
04/2006
1CollagenIBA
12/2005
1EnzymesIBA
10/2005
1ImmunosorbentsIBA
10/2005
1N(6)-(delta(2)-isopentenyl)adenine (IPADE)IBA
09/2005
1CytokininsIBA
09/2005
1KinetinIBA
09/2005
1Calcium-Binding ProteinsIBA
09/2005
1Phospholipid Transfer ProteinsIBA
02/2004
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
02/2004
1acetamideIBA
05/2003
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
05/2003
1Caspase 3 (Caspase-3)IBA
05/2003
1hexamethylene bisacetamide (HMBA)IBA
05/2003
1Butyrates (Butyrate)IBA
05/2003
1InterferonsIBA
05/2003
1Phospholipids (Phosphatides)FDA LinkGeneric
05/2002
11,25-dihydroxyvitamin DIBA
05/2002
1Hemin (Panhematin)FDA Link
05/2002

Therapy/Procedure

5Therapeutics
05/2018 - 01/2005
1Aftercare (After-Treatment)
05/2018
1Radiotherapy
03/2018
1Drug Therapy (Chemotherapy)
03/2018